Endogenus Toxicology

Many pathologic disease can be considered as related to an Endogenous toxicological movens and in time dependent way ( kinetics and dynamic of the process).In this work starting from the analisys of relevant literature involved with different disease and related to the endogenous local micro- environment some global conclusion useful as new tools for innovative pharmacological strategies will be submitted to the researcher .Physiology, pathology concept linked to the endogenous toxicological local micro-environment status as new research intruments.The same carcinogenesis process can be related also to endogenous agents that may have a major contribution in spontaneously process. (reactive oxygen species (ROS), which are involved in multiple cellular processes by physiologically transporting signal as a second messenger or pathologically oxidizing DNA, lipids, and proteins).