![Effectiveness of LU-177-dotatate after selective catheterization of the hepatic artery in inoperable metastasized liver tumors](http://shop.autorenwelt.de/cdn/shop/files/be8506b7-3395-47f8-8976-be2d129d0d0e_large.jpg?v=1727500761)
Autorenfreundlich Bücher kaufen?!
![](http://shop.autorenwelt.de/cdn/shop/t/31/assets/autorenanteil.png?v=22760640031373637041495968459)
Beschreibung
Doctoral Thesis / Dissertation from the year 2016 in the subject Medicine - Neoplasms, Oncology, , language: Modern Greek, abstract: The aim of this study is to evaluate the effectiveness of Lu-177-DOTATATE infusions after selective catheterization of the hepatic artery in inoperable metastasised liver, sst2 receptor-positive neuroendocrine tumours due to the effect of ¿-emission, minimising in parallel the toxicity of non-target tissue.
The average dose per session administered monthly to each patient (14 cases in total) was 6.3±2.3 GBq. Repetitions did not exceed 6-fold. Response assessment was classified according to the Response Evaluating Criteria in Solid Tumours. CT/ MRI scans were performed as baseline before, during and after the end of treatment, and monthly ultrasound images for follow-up measurements. Toxicity (World Health Organization criteria) was measured using blood and urine tests of renal, hepatic and bone marrow function.
¿one patient was achieved complete response[CR], partial response[PR] was shown in 9/14 (65%), and disease stabilization[SD] in 2/14 (14%) patients; three patients (21.0%) did not respond [PD]. Grade 1 erythro-, leuko- and thrombo-cytopenia occurred in 8 cases, grade 2-3 in 4 cases and blood transfusion (grade 4) in 2.
In unresectable metastatic liver lesions positive for somatostatin receptors repeated, trans-hepatic high doses of Lu-177-DOTA-TATE show an effective therapeutic outcome. No nephro- or liver-toxicity has so far been observed. The observed myelo- toxicity was appropriately managed.
Details
Verlag | GRIN Verlag |
Ersterscheinung | September 2016 |
Maße | 21 cm x 14.8 cm x 0.8 cm |
Gewicht | 157 Gramm |
Format | Softcover |
ISBN-13 | 9783668299245 |
Auflage | 1. Auflage |
Seiten | 100 |