Effect of generation G on cancer targeting propensity of PPI dendrimer

This book discussed the single platform assessment of targeting potential of anticancer drug loaded plain as well as folate anchored PPI dendrimer of different generations. This is the debut study to explore the effect of generation on the drug delivery aspects of plain and folate-conjugated PPI dendrimer. Folic acid used as a model targeting ligand due to its promising acceptability in cancer targeting. The folate conjugation is also expected to enhance biocompatibility of cationic dendrimer due to shielding of peripheral cationic groups. It is anticipated that the the developed dendrimer-based nano-formulation will generate a safe, effective and stable formulation that will help in successful transformation of dendritic formulations from laboratory to clinical stages.