Effect of Colesevelam and Atorvastatin on Hyperlipidemia disease.

Atherosclerosis is a major cardio effective disorder that affects heart causing hyperlipidemia which blocks the artery, aorta and obstruct the pathway of blood flow which puts life at risk. The modern medication needs to be administered continuously and in higher doses which leads to negative drawbacks. The study aim is to give the Combination therapy treatment as per the drug mechanism of action is known and how bioavailability is also known. Five group of albino wistar rats were being experimented in this case, group I to V i.e. NC, DC, COL, ATS(40mg/kg) and ATS(10mg/kg) + COL is to give the treatment as chronopharmacology method in combination and in low dose range of atorvastatin 10-20 mg/kg less side effect is observed. Conducting the study is seen that lower dose in combination (bile acid sequestrants and HMG- CO-A inhibitor) was proven that CK-MB levels are decreased in comparison of high dose of Atrorvastatin by Detection of Biochemical Evaluation Parameters like CK-MB, Lipid profile, CBC etc. As further it will comes in future work can be done into cell line on molecular base to determine clinical significance.