Does estrogen deficiency cause hepatic disorders?

The loss of ovarian hormone after menopause is linked to many pathophysiological reactions. The question is, does liver affected by estrogen decline. Bilateral ovariectomy in the animal model was used for studying the effects of ovarian hormone deficiency in human menopause. The ovariectomized (OVX) rat model remains the most popular choice as it has been proven to represent some of the most important clinical features of postmenopausal women. Therefore, the present study evaluate the efficacy of Cicer arietinum extract on the hepatic disorders in OVX rat. This work revealed that there is not severe hapatic damage resulted by estrogen depletion at least under the condition of the present study.