Dietary vegetable oil consumption on glucose levels, in diabetic mice

Increasing evidence implicates dietary fat composition in the development of insulin resistance, including impaired fasting glycaemia and Type 2 diabetes mellitus. Most patients with type 2 diabetes are obese and have elevated plasma free fatty acids concentrations and these have been shown to inhibit insulin-stimulated glucose uptake. The Randle glucose-fatty acid cycle has been used to explain insulin resistance in skeletal muscle of patients with type 2 diabetes or obesity. Here we show that some plant vegetable oils: Groundnut (Arachishypogaea) oil, Red palm (Elaeisguineensis) oil and coconut (Cocosnucifera) oil rather stimulate glucose uptake in type 2 diabetic mice fed on 10% by weight of these vegetable oil in rodent chow. The oils did not impair glibenclamide effect on diabetes management and did not induce dyslipidaemia. This finding should be exciting to clinicians looking for new challenges in diabetes management, medical students, and students in clinical chemistry and researchers in diabetes mellitus