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Some novel hybrid 1,3-thiazine-1,3,5-triazine derivatives were synthesized and tested for antibacterial activity. Compounds were found active against Gram positive and Gram negative microorganisms.Excellent to moderate antibacterial activity was presented by the target compounds. The structures of all these newly synthesized compounds were confirmed by their elemental analyses and spectral data techniques viz. IR, 1H NMR, 13C NMR, and mass spectroscopy.