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Beschreibung
This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.
The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.
McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area.
Details
| Verlag | Springer International Publishing |
| Ersterscheinung | 22. April 2018 |
| Maße | 23.5 cm x 15.5 cm |
| Gewicht | 265 Gramm |
| Format | Softcover |
| ISBN-13 | 9783319817675 |
| Auflage | Softcover reprint of the original 1st ed. 2016 |
| Seiten | 144 |
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