Comparative study of Fasting and postprandial dyslipidemia in Type2 DM

Type 2 Diabetes Mellitus (DM) is characterized by insulin resis­tance which is associated with glucose intolerance, hypertension, dyslipidaemia, a procoagulant state, and an increase in the mi­crovascular and the macrovascular disease. Diabetics are frequently hyperlipidemic and they are at a high risk for coronary heart disease. The high cardiovascular mortality which is as­sociated with Type 2 DM is due to a prolonged, exaggerated, postprandial state. The postprandial dysmetabolism and the associated oxidative stress may link the insulin resistance and the Type 2 DM to the disproportional incidence of cardiovascular disease. Postpran­dial hypertriglyceridaemia has been linked to asymptomatic and symptomatic macrovascular diseases in both normo or hy­pertriglyceridaemic subjects and such abnormalities have been reported in the type 2 diabetics. The increased risk of atheroscle­rosis among them, may therefore, be related to the higher post­prandial lipaemia in them. The postpran­dial dysmetabolism and the associated oxidative stress may link the insulin resistance and the Type 2 DM to the disproportional incidence of cardiovascular disease.