Chromosome Segregation and Aneuploidy

Aneuploidy - the greatest genetic affliction of man - has

its origin in manycellular processes. Its forerunner,

chromosome non-disjunction, can result from malfunction of

one of many processes involved in faithful segregation of

chromosomes during mitosis or meiosis.

Experts on chromosome biology,centromere, kinetochore,

microtubules, spindle apparatus, biochemistry of mitosis and

meiosis, developmental biology, and environmental

mutagenesis discuss basic and applied aspects of how

chromosomes malsegregate and how aneuplody originates.

The most recent techniques employed to study chromosome

segregation and also methods to determine aneugenic

chemicals are described.