Choloroquine

It all began in 1971 at the Department of Physiology of Ghana Medical School when an injection of chloroquine into the gastrocnemius of an in vivo nerve muscle preparation of an anaesthetised dog demonstrated a reversible reduction in muscle twitch contractions. This finding was studied further in detail including experiments with microelectrode at the end plate in frogs. Over a period of five years and later, experiments in various systems, organs and tissues were carried out at the same laboratory. This project spanning 43 years is here published in the book entitled Chloroquine: Review & Experimental Study of its Therapeutic & Adverse Properties authored by Professor Herbert Mapfumo Chinyanga (Emeritus) and Professor George A. Vartanian (WHO) and edited by Professor R. A. Gordon (University of Toronto, Ontario, Canada).