Chemistry of some Thienopyrimidine derivatives

Thienopyrimidines are potential bioactive molecules as they are structural analogs of biogenic purines and can be considered as potential nucleic acid antimetabolites. They are interesting scaffolds associated with multiple biological activities including analgesic ,anti-inflammatory, antimicrobial and antiproliferative activities.Herein,we focused on the design and synthesis of cyclohepta[4,5]thieno[2,3-d]pyrimidine derivatives investigating their PARP inhibitory and antioxidant activities.PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADPribose polymerase.Poly(ADP-ribosyl)ation mediated by PARP enzymes causes chromatin decondensation around damage sites, and accelerates DNA damage repair.PARP-1 inhibitors are developed for multiple indications;the most important is the treatment of cancer.PARP inhibitors are considered a potential treatment for some life-threatening diseases as stroke and inflammation.While antioxidants act as a major defense against radical mediated toxicity by protecting the damages caused by free radicals.Antioxidant agents are effective in the prevention and treatment of complex diseases as stroke,Alzheimer and cancer.