Cardiovascular Disease Genes Polymorphisms And Recurrent Miscarriage

Recurrent miscarriage is defined as 3 or more consecutive pregnancy losses before 20 weeks of gestation. It affects 5% of pregnancies, and, unfortunately, most of the cases are of unknown causes. Inherited thrombophilias have been postulated as an etiology, with a large and contradictory literature addressing their link to recurrent spontaneous miscarriage. This manuscript contains a review of this literature, and the retrospective case control study done by my colleagues and I on a cohort of the Lebanese population,aiming to find weather or not there is an association of 12 different thrombophilia genes with recurrent pregnancy loss, weather this association is mono or multi-genetic, and weather there are other factors, such as life style habits or environmental factors, that could increase, or decrease the risk of recurrent pregnancy loss.