BRCA-related breast cancer: characterization and management

It is estimated that 5-10% of breast cancers develop in the context of a genetic predisposition linked to the transmission of major susceptibility genes. BRCA1/2 are the genes most involved in the hereditary form of the disease. The aim of this book is to provide an update on BRCA-related breast cancer, the molecular characterization of these genes and the medical management of those at risk. Individuals carrying a germline mutation in these genes are at high risk of breast, ovarian and, to a lesser extent, fallopian tube, pancreatic and prostate cancer. BRCA genes are characterized by a broad mutational spectrum, which varies from country to country. The identification of BRCA mutation carriers enables personalized treatment, with the major benefit of reducing breast cancer morbidity and mortality. This book will be of interest to medical students, oncologists, geneticists, radiation therapists and doctors of genetics.