Bio Cell Technology

Many neurodegenerative diseases are related to neuronal death, mainly to oxidative stress. Several studies show that hydrogen peroxide can cause cell damage resulting in neuronal death, but at the same time, other research indicates that hydrogen peroxide, at low concentrations, can participate in the activation of neuronal survival pathways or act as a neuromodulator in the activity of neuronal cells. The purpose of the present study was to evaluate the in vitro effect of hydrogen peroxide on neuronal cell cultures and the activation of the enzyme neuronal nitric oxide synthase through neuromodulation of the MAPK-ERK1/2 mitogenic and neuronal survival signaling pathways.