Anticancer activity and targeted delivery of metal-based drugs

In this thesis, promising representatives of approved and novel metal-based drugs containing arsenic, ruthenium and platinum were analyzed for their anticancer activity. Strategies such as drug combinations, polymeric nanoformulations, and drug structure modifications were employed to increase their anticancer activity, overcome drug resistance, and reduce side effects. Summarizing, these studies suggest that metal-based drugs are promising anticancer therapeutics that can be further improved in their anticancer activity by structural modifications, combination with targeted therapeutics, as well as application of biodegradable drug carriers for targeted delivery.