Antiamoebic Agents-Phytochemistry

It is by God's grace, blessings and His will that I accomplished this work. No amount of words can completely express my deep sense of gratitude in acknowledging all those who directly or indirectly have helped me throughout the work. Protozoan parasites are among the most common pathogens in the world and are recognized as the causative agent of various tropical diseases in both man and domestic animals. Malaria, amoebiasis, toxoplasmosis, trypanosomiasis and leishmaniasis are diseases caused by protozoan parasites that affect approximately 25 % of the worlds population, mostly in developing countries causing loss of lives and productivity. Amoebiasis, a disease caused by ingestion of contaminated food or water containing cysts of E. histolytica, an early-branching protozoan eukaryotic remains one of the major threats to public health in most parts of the globe. It infects over 50 million people per annum leading to 50,000 to 100,000 deaths annually. During the last 50 years a number of compounds have been isolated and/or synthesized for the treatment of Amoebiasis.