Anti- Ulcerarogenic Potential of Ficus bengalensis Leaves Extract

The present study was carried out to investigate antiulcer activity of aqueous extract of Ficus bengalensis leaf in pylorus ligation, alcohol induced, aspirin induced and stress induced ulcers (CRS) in the rats. Pylorus ligation induced ulcer is one of the most widely used methods for studying the effect of drug on gastric secretion. Effect of distilled water in pylorus ligation has caused the accumulation of gastric sectretion and decreased the pH. The total acidity, free acidity, ulcer score, number of ulcer and ulcer index of gastric secretions were increased. The anti ulcer activity was assessed by determining and comparing the ulcer index in the test drug groups with that of the vehicle control and standard ranitidine & sucralfate.The findings of the present study explored the antioxidant potential of the plant extract by 1,I-diphenyl, 2-picryl hydrazyl (DPPH) radical scavenging activity, hydroxyl radical scavenging activity, reducing capacity and hydrogen peroxide activity. The reducing capacity of a compound may serve as a significant indicator of its potential antioxidant activity.