Adenosinergic and autophagic mechanisms in Huntington's diseases

Huntington disease is a complex neurodegenerative disorder. Presently, it is being treated sympatomatically based on patient symptoms/ condition. Present work is an attempt of authors to share their observation that treatment with caffeine and dipyridamole displayed significant protection highlighting their neuroprotective efficacy in HD like conditions.This further confirmed that targeting adenosinergic system could be an important therapeutic strategy in the management of HD like symptoms. Further, it has been observed that treatment with rapamycin caused marked improvement in the QA induced behavioural (motor and memory) alteration, oxidative burden, mitochondrial dysfunction, neuroinflammation, apoptosis, neurotrophin levels highlighting role of autophagy in excitotoxic conditions.