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"The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins."
Tags: Medizin, Nichtklinische Fächer
Taschenbuch - 9783642428173
Verlag: Springer Berlin Heidelberg
Ersterscheinung: Januar 2014
Größe: 235 mm x 155 mm x 13 mm
Gewicht: 380 Gramm
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Hardcover - 9783642228001
Verlag: Springer-Verlag GmbH
Ersterscheinung: November 2011
Größe: 246 mm x 164 mm x 23 mm
Gewicht: 506 Gramm