Actinides and Abiogenesis of Life on Earth

Endogenous digoxin has been related to the pathogenesis of schizophrenia, malignancy, metabolic syndrome x, autoimmune disease and neuronal degeneration. The possibility of endogenous digoxin synthesis by actinide based primitive organism like archaea with a mevalonate pathway and cholesterol catabolism was demonstrated as an important pathology of these diseases. An actinide dependent shadow biosphere of archaea and viroids in the above mentioned disease states has been described. Metal actinides in beach sands have been postulated to play a role in abiogenesis. A hypothesis of cholesterol as the primal prebiotic molecule synthesised on actinide surfaces with all other biomolecules arising from it and a self-replicating cholesterol lipid organism as the initial life form is presented. This can be called as the isoprenoid organism creating a shadow biosphere of actinidic archaea and archaeal viroids. The actinidic archaea live by catabolizing cholesterol as its source of energy.