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Beschreibung
This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements.
The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design.
Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.
A Structural, Functional and Evolutionary Analysis
A Structural, Functional and Evolutionary Analysis
Details
| Verlag | Springer Singapore |
| Ersterscheinung | 26. November 2019 |
| Maße | 23.5 cm x 15.5 cm |
| Gewicht | 348 Gramm |
| Format | Hardcover |
| ISBN-13 | 9789811374494 |
| Seiten | 101 |
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