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Beschreibung
In this study, we investigated the role of acid sphingomyelinase in demyelination and myelin repair by inducing acute and chronic demyelination with 5- or 12-week cuprizone treatment, followed by a 2-week cuprizone withdrawal phase to allow myelin repair.Our findings suggest that acid sphingomyelinase plays a significant role in myelin repair, and its inhibition by amitriptyline may constitute a novel therapeutic approach for multiple patients.
Details
| Verlag | LAP LAMBERT Academic Publishing |
| Ersterscheinung | 12. Juli 2017 |
| Maße | 22 cm x 15 cm x 0.5 cm |
| Gewicht | 113 Gramm |
| Format | Softcover |
| ISBN-13 | 9783330344778 |
| Seiten | 64 |