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Beschreibung
This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.
Details
| Verlag | Springer Berlin |
| Ersterscheinung | 21. April 2013 |
| Maße | 23.5 cm x 15.5 cm |
| Gewicht | 149 Gramm |
| Format | Softcover |
| ISBN-13 | 9783642267055 |
| Auflage | 2011 |
| Seiten | 74 |
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