Systems biology

Source: Wikipedia. Pages: 66. Chapters: Gene regulatory network, Synthetic biology, Metabolomics, Two-hybrid screening, Flux balance analysis, Metabolic network modelling, Cell signaling, SBML, List of systems biology research groups, Ionomics, Biopunk, Modelling biological systems, Metabolic control analysis, Interactome, Minimum Information Required in the Annotation of Models, Genenetwork, Dynamic energy budget, Protein¿protein interaction, Society for Mathematical Biology, STRING, Systems Biology Ontology, List of omics topics in biology, Cytoscape, Cellular model, Metabolome, BioModels Database, Interactomics, Systems Biology Graphical Notation, Wagner's gene network model, DAVID, GenMAPP, The Proteolysis Map, International q-bio Conference on Cellular Information Processing, Luxembourg Centre for Systems Biomedicine, Manchester Centre for Integrative Systems Biology, KEGG, Phenome, Minimum Information About a Simulation Experiment, Biochemical systems theory, Simulated growth of plants, Biological systems engineering, Gemini Somatics, NCI-Nature Pathway Interaction Database, Biosimulation, Metallome, BioPAX, Regulome, Institute for Systems Biology, Living systems, Molecular Systems Biology, List of systems biology conferences, Network theory of aging, List of systems biology visualization software, BISC, Extrapolation based molecular systems biology, ChemProt, Systems immunology, Department of Systems Biology, Human ecosystem, Systems Biology Ireland, Protein-DNA interaction, Centre for Plant Integrative Biology, ESIGNET Project, BMC Systems Biology, Interaction network, Interferomics, Metabolic flux analysis, Metabolite pool. Excerpt: Synthetic biology is a new area of biological research that combines science and engineering. It encompasses a variety of different approaches, methodologies and disciplines, and many different definitions exist. What they all have in common, however, is that they see synthetic biology as the design and construction of new biological functions and systems not found in nature. A light programmable biofilm made by the UT Austin / UCSF team during the 2004 Synthetic Biology competition, displaying "Hello World" The term "synthetic biology" has a history spanning the twentieth century. The first use was in Stéphane Leducs¿s publication of « Théorie physico-chimique de la vie et générations spontanées » (1910) and « La Biologie Synthétique » (1912). In 1974, the Polish geneticist Waclaw Szybalski used the term "synthetic biology", writing: Let me now comment on the question "what next". Up to now we are working on the descriptive phase of molecular biology. ... But the real challenge will start when we enter the synthetic biology phase of research in our field. We will then devise new control elements and add these new modules to the existing genomes or build up wholly new genomes. This would be a field with the unlimited expansion potential and hardly any limitations to building "new better control circuits" and ..... finally other "synthetic" organisms, like a "new better mouse". ... I am not concerned that we will run out of exciting and novel ideas, ... in the synthetic biology, in general. When in 1978 the Nobel Prize in Physiology or Medicine was awarded to Arber, Nathans and Smith for the discovery of restriction enzymes, Waclaw Szybalski wrote in an editorial comment in the journal Gene: The work on restriction nucleases not only permits us easily to construct recombinant DNA molecules and to ana...