Studies in Development of Fluid Bed Granulation Technology

The fluid bed granulation is a fairly complex process that can be divided in three steps: (1) Wetting and nucleation, (2) consolidation and growth and (3) breakage and attrition. Process parameters and physicochemical properties of the binder and granule substrate can have significant impact on these rate process and consequently the physical properties of the granule formed. The fluid bed granulation process is a influenced by various processing parameters like atomization pressure, binder addition rate, in let temperature, binder concentration etc. These process variables largely affect the granulation efficiency and the final granule characteristics so one should consider the process variable effect on granulation mechanism while developing a fluid bed granulation process for the any kind of the material that is to be granulated via this process. Granules prepared by this technology generally have good flow property but % porosity of the granules is higher then the granules prepared by the other convention granulation technique, has a good compressibility; and good flowability.