Schiff Bases Transition Metal complexes in Bio-medical Applications

Metal complexes have a great influence in many areas such as bio-inorganic chemistry, medicinal chemistry and coordination chemistry etc. Coordination compounds have played prime role in catalytic processes and biological systems. Among the organic compounds, Schiff bases attract the attention of researchers because of their synthetic flexibility and wide applicability in biological sciences. The Schiff bases derived from o-hydroxyaldehydes and aminothiazole possess strong ability to form complexes with transition metals and rare earths as well. Thiazoles are well known as biological important compounds and they exhibits wide spectrum of biological (antibacterial, antifungal, antiviral and antitumor) activities. Microwave (MW) mediated synthesis of thiazoles and Schiff bases deserve proper attention of researchers in the fields of green chemistry on the ground of reduction in reaction time and saving in energy.Conventional method of synthesis of aminothiazole requires 12 hours heating on water bath whereas microwave mediated synthesis completes within a couple of minutes. Microwave mediated synthesis of Schiff bases requires 20 to 30 seconds for completion.