Role of Human Cytokine IL17, IL20 and IL22 with severity of Psoriasis

Psoriasis is an ancient, non contagious, universal immune mediated inflammatory, polygenic chronic skin disease affecting 2-3% population worldwide. The pathogenesis of psoriasis has not been clearly understood so far. Present study comparing the serum level of human cytokines of IL-17, 20 and 22 in the severity of the psoriasis and to correlate the surface area of psoriatic lesions with quality of life in north Indian population. This study provides data on total surface area affected in severe cases and its association with quality of life and also explore the role of IL-17, 20 and 22 in the severity of the psoriasis. IL-17, 20 and 22 stands as the therapeutic target in psoriasis and several new drugs should be explored which inhibit IL-17, 20 and 22 signal transduction pathways and Th 17 gene expression. So, serum level of IL-17, 20 and 22 can be useful for diagnostic purpose and helpful in the pharmacogenomics for the development of antipsoriatic drugs. Our data indicated that human cytokines IL-17, 20 and 22 were elevated in the sera of psoriatic patients and reveals that cytokine producing skin cells may play a vital role in the pathogenesis of disease.