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Beschreibung
In the current study, a novel in vivo DNA packaging method using the JCV VLP was employed to obtain more highly efficient gene transfer. A reporter gene, the green fluorescence protein (gfp), and a suicide gene, the herpes simplex virus thymidine kinase (tk), were encapsidated into VLPs in E. coli. The VLP was used to specifically target human colon carcinoma (COLO-320 HSR) cells in a nude mouse model. Intra-peritoneal administration of ganciclovir (GCV) in the tk-VLP treated mice greatly reduced tumor volume. These findings suggest that it will be possible to develop the JCV VLP as a gene delivery vector for human colon cancer therapy in the future.
Details
| Verlag | ¿¿¿¿¿¿¿ |
| Ersterscheinung | 15. März 2017 |
| Maße | 22 cm x 15 cm x 0.5 cm |
| Gewicht | 125 Gramm |
| Format | Softcover |
| ISBN-13 | 9783330822207 |
| Seiten | 72 |
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