Host Modulation and Host Modulating Agents

Periodontitis is an inflammatory disease induced by microbes leading to destruction of tooth supporting structures.Host inflammatory response contributes to the main damage and clinical signs of the disease.This modality of treatment of host part of the disease is called as Host Modulating Therapy (HMT). It is a valuable innovation in the management of Periodontal disease that aims to reduce tissue destruction and help to even regenerate the periodontium by modifying the host response.The use of host Modulation Agents as an adjunct to periodontal therapy not only aims to reduce the severity of disease but also susceptibility of host towards the disease.HMT is targeted to regulate immune and inflammatory response by maintaining the balance between pro-inflammatory and anti-inflammatory mediators.Till date Subantimicrobial dose doxycycline (SDD) has been approved by FDA for use in patients and other numerous agents are under research.