Eco-Friendly Synthesis of Multi-Component Reactions

Organic synthesis involving less environmentally unfriendly processes and under solvent-free conditions has been investigated worldwide due to stringent environment and economic regulations. The characteristic aspect of MCRs is that the final products contain almost all portions of substrates, generating almost no by-products. That makes MCRs an extremely ideal and eco-friendly reaction system. Target molecule can be obtained in one pot with much fewer steps. Therefore, MCRs have been paid much attention in various research fields, such as discovery of lead compounds in medicinal chemistry or contributional chemistry. The increasing requirement for environmentally clean technology that minimizes the production of waste at source. Ultrasound may offer cleaner reactions by improving product yields and selectivities, enhancing product recovery and quality through application to crystallization and other product recovery and purification processes. Recently, mechanochemistry came into attention for the synthesis of organic molecules because of its several "green chemistry" advantages: Reaction are run without solvents, Reduced energy requirements, Little pollution and Low cost.