Donor-Acceptor Cyclopropapyranone

My primary research interests center on the Organic Synthesis and study of Donor-Acceptor cyclopropane chemistry. Research activities include the impact of D-A cyclopropanes and cyclobutanes in organic synthesis and its application towards natural product synthesis. An intramolecular, stereoselective cyclopropanation of vinylogous carbonates with carbenes using copper catalyst is developed for the synthesis of donor-acceptor substituted cyclopropapyranones. Completely regioselective ring cleavage of each of the cyclopropane bonds was achieved under suitable reaction conditions, leading to a diverse array of cyclic ethers. The developed method is utilized in the total synthesis of ()-diospongin B.