Correlation of PPAR & Diabetic Nephropathy

Diabetic nephropathy (DN) is an important and often life-threatening microvascular complication of diabetes mellitus (DM). It is characterized by persistent albuminuria in the range of 30¿299 mg/24 h (microalbuminuria), it has been shown to be the earliest sign of renal change.Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that play pivotal roles in the regulation of a very large number of biological processes, such as cell proliferation, cell differentiation, cell death, and inflammatory responses. PPARs include three known subtypes PPAR ¿, PPAR ¿, and PPAR¿/¿. It plays many functional roles in different organs and tissues; adipocyte differentiation, lipid and glucose homeostasis, and insulin sensitivity.