Biomaterials and wound induced oxidative stress

This book endows with an impression of the basis and ways to better understanding of biomaterials and management of oxidative stress and induced damages. Oxidative stress occurs when the production of oxidants surpasses the antioxidant capacity in living cells. Oxidative stress is implicated in a number of pathological conditions such as cardiovascular and neurodegenerative diseases but it also has crucial roles in the regulation of cellular activities. Over the last few decades, many studies have identi¿ed signi¿cant connections between oxidative stress, in¿ammation and healing. In particular, increasing evidence indicates that the production of oxidants and the cellular response to oxidative stress are intricately connected to the fate of implanted biomaterials. It provides an overview of the major mechanisms underlying the link between oxidative stress and the biocompatibility of biomaterials. ROS, RNS and lipid peroxidation products act as chemo-attractants, signaling molecules and agents of degradation during the in¿ammation and healing phases.