Biochemical study of Toxicity in Inorganic Salts

It was observed that the chronic dose of lead caused an elevation in the level of proteins, acid phosphatase, alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase in all the soft tissues studied indicating tissue damage, whereas it was observed be me (Dhir) the effects were more severe in case of cadmium. However no literature was available so far as to compare the toxicity level of cadmium with lead (because the cadmium ions or compounds are available in trace amount but I (Dhir) cannot rule out the possibility of cadmium pollution). Therefore it is necessary to compare lead with cadmium. Cadmium also inhibited the level of acetylcholinesterase in all the tissues. Fertility tests by pairing treated females with males showed that lead and cadmium treated female showed irregular oestrous cycle and the fertility rate dropped to 40 %(in case of lead) and 50 % (in case of cadmium) as female pups of lead treated mothers showed loss in weight, high mortality rate, poor growth rate and late vaginal opening. Histological studies of ovary showed atresia (figures-5-8) in all the stages of folliculogenesis sustaining the poor fertility observations.