Antiseizure Potential of Angelica Plant

Nature is a rich source of biological and chemical diversity and a number of plants in the world have been used in traditional medicine remedies, i.e., anticonvulsant, anxiolytic, analgesic, antidepressant. Epilepsy is a chronic and often progressive disorder characterized by the periodic and unpredictable occurrence of epileptic seizures which are caused by an abnormal discharge of cerebral neurons. Anticonvulsant drugs are used to control the convulsions by inhibiting the discharge and then producing hypnosis. This book illustrate about the essential oil of the root of Angelica archangelica suppressed duration of tonic convulsions and showed recovery in maximal electroshock induced seizures while it delayed time of onset of clonic convulsions and showed mortality protection in pentylenetetrazol induced seizures. It also produces motor impairment at the antiseizure doses. The antiseizure effect may be attributed to the presence of terpenes in the essential oil.