Antiobesity drugs

Source: Wikipedia. Pages: 69. Chapters: Anorectics, Cocaine, Amphetamine, Khat, Methamphetamine, Dextroamphetamine, Orlistat, Anti-obesity medication, Sibutramine, Exenatide, Lorcaserin, 2,4-Dinitrophenol, Phenylpropanolamine, Rimonabant, Phentermine, Propylhexedrine, Tesofensine, Oleoyl-estrone, Phenmetrazine, Fen-phen, Fenfluramine, Phentermine/topiramate, Vabicaserin, Dexfenfluramine, Benfluorex, Aminorex, Bupropion/naltrexone, Amfepramone, P57, Taranabant, Benzphetamine, 4-Methylamphetamine, Phendimetrazine, Fencamfamine, Levopropylhexedrine, SNAP-94847, Dirlotapide, Difemetorex, Clobenzorex, Chlorphentermine, Cetilistat, Amfecloral, Clortermine, Fenbutrazate, Furfenorex, Simmondsin, Xylopropamine, Levophacetoperane, NGD-4715, Bupropion/zonisamide, GW-803,430, Indanorex, Cloforex, Amfepentorex, Etolorex, Oxyntomodulin, Setazindol, Azalanstat, Tiflorex, TM38837, Methastyridone. Excerpt: Cocaine (benzoylmethylecgonine) (INN) is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine. It is a stimulant of the central nervous system, an appetite suppressant, and a topical anesthetic. Specifically, it is a serotonin¿norepinephrine¿dopamine reuptake inhibitor, which mediates functionality of these neurotransmitters as an exogenous catecholamine transporter ligand. Because of the way it affects the mesolimbic reward pathway, cocaine is addictive. Its possession, cultivation, and distribution are illegal for non-medicinal and non-government sanctioned purposes in virtually all parts of the world. Although its free commercialization is illegal and has been severely penalized in virtually all countries, its use worldwide remains widespread in many social, cultural, and personal settings. Data from The Lancet suggests cocaine is ranked both the 2nd most addictive and the 2nd most harmful of 20 popular recreational drugs.Cocaine is a powerful nervous system stimulant. Its effects can last from 15¿30 minutes to an hour, depending upon the method of ingestion. Cocaine increases alertness, feelings of well-being and euphoria, energy and motor activity, feelings of competence and sexuality. Athletic performance may be enhanced in sports where sustained attention and endurance is required. Anxiety, paranoia and restlessness are also frequent. With excessive dosage, tremors, convulsions and increased body temperature are observed. Occasional cocaine use does not typically lead to severe or even minor physical or social problems. With excessive or prolonged use, the drug can cause itching, tachycardia, hallucinations, and paranoid delusions. Overdoses cause tachyarrhythmias and a marked elevation of blood pressure, which can be life-threatening. Side effects of chronic cocaine use Cocaine hydrochlorideChronic cocaine intake causes brain cells to adapt funct