An anti-hyperglycemic molecule, RNF01

This book was written to study the antihyperglycaemic activity of the RFN01 extract in mice. In vivo tests were performed in mice made hyperglycaemic after glucose overload (2 g/kg, per os) and by alloxane injection (150 mg/kg, i.p.). RNF01 reduced the transient hyperglycaemia induced by glucose overload to 6.85 ± 0.24 mmol/l and 5.95 ± 0.62 mmol/l at 400 mg/kg and 500 mg/kg compared to the control which was 8.85 ± 0.62 mmol/l (p<0.05) Two days after the alloxane injection, the blood glucose level of the mice increased to 12.26 ± 0.26 mmol/l, but the RNF01 extract administered orally at a dose of 500 mg/kg reduced the blood glucose level to 8.42 ± 0.36 mmol/l. The presence of flavonoids and alkaloids in RNF01 extract could be responsible for its hypoglycaemic effect.