¿- Amylase inhibitory activity of basella rubra

Diabetes mellitus is a common metabolic disorder that increases the postprandial glucose level which may leads to multiple organ damage and the risk of cardiovascular diseases which is the most common cause of death among the people with diabetes. Management of blood glucose level is critical in the early treatment of diabetes mellitus and its complication. Sharp rise in the blood glucose level after food intake from the intestine is aided by ¿-Amylase enzymes which break the carbohydrate to simple absorbable sugars. Synthetic enzyme inhibitor such as acarbose, miglitol, voglibose are useful as oral hypoglycemic drugs for the control of post prandial hyperglycemia especially in type II diabetes patients. These inhibitors delay carbohydrate digestion and it prolongs the time taken for the glucose absorption in intestine. A chronic usage of these inhibitors in conjunction with other antidiabetetic drugs leads to GI side effects like abdominal discomfort, flatulence and diarrhea. Several plants have been identified as the potential source of drugs in Indian system of medicine for the treatment of diabetes. Based on literature review and present phytochemical investigation found that