{"product_id":"virus-host-cell-interplay-in-cancer-progression-von-fang-cheng","title":"Virus-host cell interplay in cancer progression","description":"\u003cp\u003eHuman tumor viruses contribute to 15-20% of human cancers worldwide. Kaposi¿s sarcoma herpesvirus (KSHV) is an etiological agent for Kaposi¿s sarcoma (KS) and two other malignancies. KS is the most common cancer in HIV-infected untreated individuals and remains a primary cause of cancer deaths in many subequatorial African countries as a result of the AIDS pandemic. This book first introduces an unbiased gain-of-function human kinome cDNA screen on KSHV reactivation in infected human cells. By developing a novel 3D cell culture model reflecting the context of virus-host cell interaction, this book further reveals the first lymphatic-specific endothelial-to-mesenchymal transition (EndMT) induced by a human tumor virus, giving rise to infected, invasive cells, and providing the virus a permissive cellular microenvironment for efficient spread of the virus. This book should shed lights on understanding the long-term persistence of oncogenic infectious agents in infected individuals, allowing time for the multi-step tumorigenesis. It should also be especially useful for professionals who are interested in developing targeted therapies to prevent or at least slow down KS progression.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659105159\"\u003e\u003ch3\u003eUnderstanding the pathogenesis of Kaposi's sarcoma herpesvirus (KSHV)\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783659105159","offer_id":39487729631325,"sku":"9783659105159","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/b4cd2108-3738-4562-b8bb-cdf297baadb3.jpg?v=1774680134","url":"https:\/\/shop.autorenwelt.de\/products\/virus-host-cell-interplay-in-cancer-progression-von-fang-cheng","provider":"Autorenwelt Shop","version":"1.0","type":"link"}