Virus-host cell interplay in cancer progression: Understanding the pathogenesis of Kaposi's sarcoma herpesvirus (KSHV)

Virus-host cell interplay in cancer progression: Understanding the pathogenesis of Kaposi's sarcoma herpesvirus (KSHV)


59,00 €
inkl. MwSt. & Versandkosten (innerhalb Deutschlands)

von Fang Cheng

Beschreibung

Human tumor viruses contribute to 15-20% of human cancers worldwide. Kaposi's sarcoma herpesvirus (KSHV) is an etiological agent for Kaposi's sarcoma (KS) and two other malignancies. KS is the most common cancer in HIV-infected untreated individuals and remains a primary cause of cancer deaths in many subequatorial African countries as a result of the AIDS pandemic. This book first introduces an unbiased gain-of-function human kinome cDNA screen on KSHV reactivation in infected human cells. By developing a novel 3D cell culture model reflecting the context of virus-host cell interaction, this book further reveals the first lymphatic-specific endothelial-to-mesenchymal transition (EndMT) induced by a human tumor virus, giving rise to infected, invasive cells, and providing the virus a permissive cellular microenvironment for efficient spread of the virus. This book should shed lights on understanding the long-term persistence of oncogenic infectious agents in infected individuals, allowing time for the multi-step tumorigenesis. It should also be especially useful for professionals who are interested in developing targeted therapies to prevent or at least slow down KS progression.


Tags: Medizin


Taschenbuch - 9783659105159
Verlag: LAP Lambert Academic Publishing
Ersterscheinung: April 2012
ISBN-13: 9783659105159
Größe: 220 mm x 150 mm x 8 mm
Gewicht: 225 Gramm
140 Seiten
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