{"product_id":"ventricular-fibrillation-novel-insights-into-pharmacology-and-mechanisms-von-charles-mugera","title":"Ventricular fibrillation: novel insights into pharmacology and mechanisms","description":"\u003cp\u003eSudden cardiac death (SCD) claims 100,000 lives in  the UK and over 400,000 in the USA. In humans the  spatial and temporal patterns of VF are poorly  characterised. However,if VF is phase dependant like  it is in animal models,then phase 2 VF would account  for 87 % of VF related sudden cardiac deaths in  humans. This would explain why most deaths (50-80 %) in the clinical setting occur within the first hours  of the onset of myocardial ischemia. In every animal  model examined to date ventricular fibrillation  exhibits 2 phases. The acute phase of VF, Phase 1  VF, occurs early in the first 30 minutes of  ischaemia and the late phase of VF, defined as phase  2 VF, occurs when irreversible myocardial necrosis  sets in after more than 90 min of ischaemia. In  animal models the second phase is by far the most  lethal phase. Ironically,the pathophysiological  mechanisms underlying phase 2 VF are poorly  understood and it remains a neglected therapeutic  target. There is an ever-growing body of evidence  suggesting that heightened sympathetic activity  combined with diminished parasympathetic activity  may be the pathophysiological mechanism underlying  the onset of phase 2 VF.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844329346\"\u003e\u003ch3\u003eAutonomic dysfunction and arrhythmogenesis post myocardial infarction\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844329346","offer_id":39469960462429,"sku":"9783844329346","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/5a7c86bd-4aef-443f-8778-2646f35fd5f6.jpg?v=1758088202","url":"https:\/\/shop.autorenwelt.de\/products\/ventricular-fibrillation-novel-insights-into-pharmacology-and-mechanisms-von-charles-mugera","provider":"Autorenwelt Shop","version":"1.0","type":"link"}