{"product_id":"vanadium-compounds-biochemical-and-therapeutic-applications-von-jean-louis-chiasson-ashok-k-srivastava-hrsg","title":"Vanadium Compounds: Biochemical and Therapeutic Applications","description":"\u003cp\u003eIn vitro and animal studies show that vanadate and other Because most cellular components contain hydroxyl and\/or vanadium compounds increase glucose transport activity and phosphate groups, vanadate reacts as shown in eq. 1, and 2 normalize glucose metabolism [1-5]. Furthermore, these with a variety of metabolites. For example, the reaction of insulin-mimetic compounds can be administered orally. Vana­ vanadate with the 2'-hydroxyl group of the cofactor NAD date enhances the phosphoprotein formation which is attrib­ generates an NADP analog, NADV (path b) [22]. NADV is uted to either the activation of protein kinases or inhibition an excellent cofactor for enzymes such as glucose-6-phos­ of protein phosphatases. Despite the interest in document­ phate dehydrogenase, 6-phosphogluconate dehydrogenase, ing the effects of vanadate on protein kinases, most reports and alcohol dehydrogenase [22]. The presence ofNADV have used indirect methods and studies with purified kinases could affect the levels of reducing equivalents in the cell, im­ show weak, if any, interaction of vanadate with kinases as portant in maintaining a normal glucose metabolism. This a group of enzymes (reviewed in Refs. [6-8]). Vanadate type of mechanism is distinct from the vanadate-induced interacts potently with phosphatases and the inhibition is NADH oxidation by plasma membranes [23]. Organic attributed to a five-coordinate vanadate complex which vanadates have been shown to substitute for organic phos­ mimics the transition state of the phosphate ester hydroly­ phates in many of the enzymes related to glucose metabolism sis reaction (reviewed in Refs. [7,9]).\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9780792337621\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Hardcover - 9780792337621","offer_id":51484251590,"sku":"9780792337621","price":106.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/4068d83b-5a84-46dc-8c5f-b152fe6646fd.jpg?v=1745467371","url":"https:\/\/shop.autorenwelt.de\/products\/vanadium-compounds-biochemical-and-therapeutic-applications-von-jean-louis-chiasson-ashok-k-srivastava-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}