{"product_id":"use-of-hla-b27pcr-technique-for-detection-of-ankylosing-spondylitis-von-anshul-shrivastava","title":"USE OF HLA-B27PCR TECHNIQUE FOR DETECTION OF ANKYLOSING SPONDYLITIS","description":"\u003cp\u003eHLA-B27 is a class I surface antigen encoded by B  locus in the Major Histocompatibility Complex (MHC)  on the short (p) arm of chromosome no.6,presents  microbial antigen to T cells. HLA B is a human gene  that provides instruction for making a protein that  plays a critical role in immune system.HLA-B27 is  strongly associated with a certain set of   autoimmune disease referred as the ¿Seronegative  Spondyloarthropathies¿, a group of disorders that  include Ankylosing Spondylitis (AS) and other  inflammatory joint diseases. It has been found that  90% of patients with this rheumatic disease have HLA- B27 antigen , compared with 10% of healthy controls.  PCR for detection of HLA-B27 is extremely accurate  and considered the standard method.  The aim of this  prospective study was to identify the positivity  rate of HLA-B27 in different age group and sex of  patients by using Sequence Specific Primer typing  (SSP)-PCR approach in a selected population,  suffering from Ankylosing spondylitis. Out of 40  samples,the positivity rate was maximum in age group  of above 50 and also analyzed that males are more  susceptible to this disease as compared to females.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844330649\"\u003e\u003ch3\u003eHLA-B27 PCR IN SPONDYLITIS DIAGNOSIS\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844330649","offer_id":39495942537309,"sku":"9783844330649","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/6759277d-aaaa-46df-a339-00f2f27bd2f9.jpg?v=1759296445","url":"https:\/\/shop.autorenwelt.de\/products\/use-of-hla-b27pcr-technique-for-detection-of-ankylosing-spondylitis-von-anshul-shrivastava","provider":"Autorenwelt Shop","version":"1.0","type":"link"}