{"product_id":"use-of-clean-chemical-technologies-in-the-synthesis-of-drug-molecules-von-mark-gronnow","title":"Use of Clean Chemical Technologies in the Synthesis of Drug Molecules","description":"\u003cp\u003eThe aim of this work was to apply green chemistry  techniques and principles, to the synthesis of  typical pharmaceutical intermediates and to bridge  the ¿gap¿ between academia and industry. Two synthetic routes have been the focus for study;  synthesis of the drug, salbutamol and secondly a  generic synthesis which combines many typical  reactions important to the pharmaceutical industry,  such as a Suzuki coupling, reduction, bromination  and  alkylation. These reactions provide opportunities to  demonstrate clean alternatives to transformations of  complex molecules which are regularly carried out by  the pharmaceutical industry. Suzuki C-C bond forming reactions were studied under  microwave activation utilising immobilised palladium  for the first time, and with significant success. A  novel, renewable, high surface area catalyst support  has been prepared and used to develop a catalyst  which is highly active in Suzuki, Heck and  Sonogashira coupling reactions.  A novel green chemistry metric has been developed.  By  measuring the electricity required for reactions  using different methods of synthesis and different  products can be compared in terms of energy  utilisation.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844303834\"\u003e\u003ch3\u003eSupported Palladium Catalysts, Microwave reactors and Clean Synthetic Routes for the Synthesis of Drug Molecules\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844303834","offer_id":39497022079069,"sku":"9783844303834","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/c4bbdcf4-d90a-413f-8024-ed5c0327eac6.jpg?v=1758778772","url":"https:\/\/shop.autorenwelt.de\/products\/use-of-clean-chemical-technologies-in-the-synthesis-of-drug-molecules-von-mark-gronnow","provider":"Autorenwelt Shop","version":"1.0","type":"link"}