{"product_id":"tumor-suppressor-gene-activity-in-lung-colon-and-breast-carcinomas-von-edward-esplin","title":"Tumor suppressor gene activity in lung, colon and breast carcinomas","description":"\u003cp\u003eThe most common cancers of adults include lung,  colon and breast carcinoma. The PP2A-A¿ gene (PPP2R1B) encodes a component of protein phosphatase 2A. The important role of protein phosphatase 2A in down regulating cell growth and the mutations of PP2A-A¿ in many human cancers suggest PP2A-A¿ is a tumor suppressor gene. Screening of cancer patient DNAs revealed alterations of PP2A-A¿ in various cancers and a germline alteration associated with breast carcinoma. Biochemical studies showed mutations in PP2A-A¿ reducing its ability to bind the PP2A complex. Transfecting the PP2A-A¿ gene into cancer cell lines conferred a relative growth disadvantage to transfected cells. Cell lines expressing  exogenous PP2A-A¿ are found to have lower levels of ¿-catenin, suggesting the PP2A-A¿ gene is involved in  regulating the Wnt signaling pathway. These studies elucidate the tumor suppressor qualities of the PP2A-A¿ gene, its role in heritable cancer susceptibility, the potential it has as a target for gene directed therapy of cancer, and should be useful to professionals studying the mechanisms and treatment of cancer.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838325002\"\u003e\u003ch3\u003ePPP2R1B mechanisms of tumorigenesis and heritable cancer susceptibility\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838325002","offer_id":39498987962461,"sku":"9783838325002","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/ac3fe082-64aa-4111-9e35-56a791df158b.jpg?v=1757741462","url":"https:\/\/shop.autorenwelt.de\/products\/tumor-suppressor-gene-activity-in-lung-colon-and-breast-carcinomas-von-edward-esplin","provider":"Autorenwelt Shop","version":"1.0","type":"link"}