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This review has been aimed at the treatment of rheumatoid arthritis and their significance. Rheumatoid arthritis is the most important systemic disease. The current review information has been found to reveal both remarkable active medicine and a variety of valuable practical applications. An interest in the exploration of this medicine has undoubtedly been growing due to their proven utility as attractive lead structures for the design of novel agents with a mechanism of action that sometimes differs from that of clinically authorized current antirheumatic drugs. Therefore, in the present review work we have focussed our attention on the information revealing rheumatoid arthritis treatment.