{"product_id":"transmethylations-and-the-central-nervous-system-von-a-agnoli-v-m-andreoli-c-fazio-hrsg","title":"Transmethylations and the Central Nervous System","description":"\u003cp\u003eV M. ANDREOLl, A. AGNOLI, and C. FAZIO The transfer of a methyl group from a donor to an acceptor compound is a fundamental biochemie al process long since known to biologists; the process is involved, for instance, in the metabolism of porphyrins, nuc1eic acids, and fatty acids. Only recently, however, did transmethylation processes reveal their decisive role in CNS biochemistry - namely with the discovery that such processes are linked with the biogenie amines that have been conc1usively identified as the chemical mediators of neu­ ronal transmission and, more broadly, of behavior. The first suggestion that transmethylation processes might be involved in the origina­ tion of certain mental diseases came from Harley-Mason (1952), who noticed that many of the hallucinogenic substances known at that time contained methyl radicals, and par­ ticularly that mescaline represented the product of O-methylation of dopamine in posi­ tions 3, 4, and 5. This hypothesis was put forward when the O-methylation of catechol­ amines by catechol-O-methyltransferases had not yet been described. Harley-Mason further proposed that in the living organism the process of O-methyla­ tion might follow a \"deviant\" metabolie pathway, and that the accumulation of abnor­ mal methylated metabolites endowed with hallucinogenic properties might be responsi­ ble for the implementation of some mental diseases, notably schizophrenia. He also called attention to a substance, 3,4-dimethoxyphenylethylamine (3,4-DMPEA) as a possible psychotogenic moleeule, on the strength of its capacity for producing cata­ tonia in experimental animals.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783642885181\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783642885181","offer_id":39431935754333,"sku":"9783642885181","price":53.49,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/03fdff67-331e-4b29-a1b0-d77edf479d73.jpg?v=1775882055","url":"https:\/\/shop.autorenwelt.de\/products\/transmethylations-and-the-central-nervous-system-von-a-agnoli-v-m-andreoli-c-fazio-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}