{"product_id":"transforming-growth-factor-beta-in-cancer-therapy-volume-ii-von-undefined","title":"Transforming Growth Factor-Beta in Cancer Therapy, Volume II","description":"Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF-~ has been linked to several diseases. For instance, the effect ofTGF-~ on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF-~ has a very complicated role in cancer that is only beginning to be understood.\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9781588297150\"\u003e\u003ch3\u003eCancer Treatment and Therapy\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Hardcover - 9781588297150","offer_id":39529926918237,"sku":"9781588297150","price":213.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/47181890-42ad-46a3-91be-31bf113420e5.jpg?v=1759379904","url":"https:\/\/shop.autorenwelt.de\/products\/transforming-growth-factor-beta-in-cancer-therapy-volume-ii-von-undefined","provider":"Autorenwelt Shop","version":"1.0","type":"link"}