{"product_id":"transcriptional-regulation-in-white-adipose-tissue-lipid-metabolism-in-white-adipose-tissue-von-khwaja-islam","title":"Transcriptional Regulation in White Adipose Tissue","description":"\u003cp\u003ePeroxisome proliferator-activated receptor (PPAR) and sterol regulatory element binding protein (SREBP) families control the transcription of genes involved in lipid metabolism. I investigated the role of PPAR¿ in regulation of lipid metabolism in white adipose tissue (WAT) in response to various metabolic challenges, measuring the expression of lipogenic (SREBP-1c, SREBP-1a, acetyl-CoA carboxylase (ACC), and fatty acid synthase (FAS)) and cholesterogenic (SREBP-2, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR), and low density lipoprotein-receptor (LDL-R)) genes and flux through the lipogenic pathway. PPAR¿-deficiency was associated with reduced epididymal fat mass but increased cholesterol concentration, an effect enhanced by feeding a diet enriched in cholesterol. Adipose tissue lipogenesis was increased in PPAR¿-deficiency, and was further enhanced by feeding a cholesterol-rich diet. The increased lipogenesis in PPAR¿-deficiency was accompanied by lower mRNA expression of SREBP-1c and its target genes, ACC and FAS. Consumption of a high-cholesterol diet increased the mRNA expression of these genes in PPAR¿-deficiency.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659820007\"\u003e\u003ch3\u003eLipid Metabolism in White Adipose Tissue\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659820007","offer_id":39450172489821,"sku":"9783659820007","price":76.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/4978dd43-ed54-4f53-8fd2-a251da5e0d8f.jpg?v=1769236006","url":"https:\/\/shop.autorenwelt.de\/products\/transcriptional-regulation-in-white-adipose-tissue-lipid-metabolism-in-white-adipose-tissue-von-khwaja-islam","provider":"Autorenwelt Shop","version":"1.0","type":"link"}